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On the high-dose sema-bima combination, patients lost exclusivley fat at 24 weeks and 90% fat mass at 48 weeks

In addition to being prescribed to help lower A1C in adults with type 2 diabetes, the medication is also used off-label for weight loss

doi: 10.1111/j.1463-1326.2009.01173.x

Last reviewed: May 24, 2026 Last updated: May 24, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Tesamorelin has direct, clinical-trial evidence for visceral fat reduction in a specific population (HIV lipodystrophy)

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